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Mecp2 mutant mice exhibit the elimination of GABA developmental shifts in CA3 pyramidal neurons at birth, with an increased glutamatergic/GABAergic postsynaptic current (PSC) ratio and hypersynchronous activity, as well as impaired metabotropic long-term depression (LTD)

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this change was proposed toward aligning the Hospital OQR, REHQR, and ASCQR policy with CMS systems implementation requirements across all quality reporting programs